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Shaanxi Kaishi Biotechnology Co., Ltd
$40
1-199 Kilogram
$35
200-499 Kilogram
$30
≥500 Kilogram
Product Description
Colistin sulfate is a polymyxin E antibiotic complex produced by Bacillus polymyxa var. colistinus and supplied as a sulfate salt for pharmaceutical and veterinary applications. It is primarily sourced as a potency-standardized active ingredient for veterinary antimicrobial formulations, with quality assessment focused on identity, potency, sulfate content, moisture, and related substances.
Colistin sulfate is the sulfate salt of a mixture of closely related polymyxin peptide substances, principally colistin A and colistin B. Unlike a conventional single-molecule API, its quality is commonly expressed by antimicrobial potency and composition rather than by a single simple molecular-weight value. The compound is also known as polymyxin E or colistins sulfate.
Colistin sulfate has CAS number 1264-72-8. Official pharmacopoeial references describe it as a sulfate salt of antibacterial substances produced by the growth of Bacillus polymyxa var. colistinus. USP defines the material by a potency equivalent to not less than 500 micrograms of colistin per milligram, while the Japanese Pharmacopoeia expresses potency in units and specifies not less than 16,000 units per milligram on a dried basis.
| Item | Specification |
|---|---|
| Product Name | Colistin Sulfate |
| Product Category | Veterinary API / Polymyxin E Antibacterial |
| CAS Number | 1264-72-8 |
| Synonyms | Colistins sulfate; Polymyxin E; Colistin sulfate salt |
| Composition | Sulfate salt of a mixture of colistin-related peptide substances, principally colistin A and colistin B |
| Representative Molecular Formula | Colistin A sulfate: C53H100N16O13·2.5H2SO4; Colistin B sulfate: C52H98N16O13·2.5H2SO4 |
| Representative Molecular Weight | Colistin A sulfate: 1414.66 g/mol; Colistin B sulfate: 1400.63 g/mol |
| Typical Appearance | White to pale cream powder |
| USP Potency Reference | Equivalent to not less than 500 micrograms of colistin per milligram |
| Japanese Pharmacopoeia Potency Reference | Not less than 16,000 units per milligram on a dried basis |
| Typical Commercial Potency | Commercial specifications commonly use potency values in IU/mg; higher-potency specifications such as 19,000 IU/mg or above may be available depending on the material and test basis |
| Standard Test Method | Pharmacopoeial identification and liquid chromatographic methods, together with microbiological potency testing as applicable |
| Typical Supporting Tests | Sulfate content, loss on drying, pH, optical rotation, sulfated ash, related substances, and microbiological quality as applicable |
| Typical Shelf Life | Commonly up to 24 months when stored in the specified conditions and original packaging |
| Storage | Store in a cool, dry place, protected from excessive heat, moisture, and contamination; follow the applicable product specification for exact conditions |
| Packaging | Common bulk packaging includes 1 kg or 5 kg inner foil bags and 25 kg fiber drums; customized packaging is available for qualified orders |
| Particle Size | Customized according to formulation and processing requirements |
| Applications | Veterinary pharmaceutical formulations, veterinary antimicrobial products, pharmaceutical manufacturing, and permitted research or formulation development |
Colistin sulfate is used as an active ingredient in veterinary antimicrobial products. Selection should take into account the intended animal species, dosage form, approved use, target market, and applicable veterinary regulatory requirements.
Colistin sulfate can be sourced as a bulk API for further manufacturing into permitted veterinary dosage forms. Potency basis, impurity profile, moisture, packaging, and analytical documentation should be established before commercial procurement.
Specified colistin sulfate materials may also be used in formulation-development or analytical applications where permitted. The selected specification should match the intended laboratory, development, or manufacturing purpose.
Colistin sulfate requires a different procurement approach from single-component small-molecule APIs. A specification stating only “high purity” does not adequately describe the material. Buyers should compare potency units, analytical basis, composition, moisture, and pharmacopoeial requirements before comparing quotations.
| Procurement Focus | What to Check | Why It Matters |
|---|---|---|
| Potency | IU/mg or micrograms of colistin per milligram, including whether the result is on a dried basis | Potency is a key quality attribute for a peptide antibiotic mixture and directly affects formulation calculations. |
| Pharmacopoeial Standard | Applicable USP, JP, or other recognized monograph and its analytical procedures | Different standards may express potency and analytical requirements using different conventions. |
| Composition | Colistin-related components and chromatographic profile where specified | Colistin sulfate is not a simple single-component API, so chromatographic characterization can provide more useful information than a generic purity percentage. |
| Moisture | Loss on drying or another validated water/moisture method | Water content can affect the reported potency basis and batch-to-batch comparability. |
| Physical Handling | Appearance, particle-size requirement, packaging, and storage conditions | These parameters influence sampling, weighing, processing, and storage during downstream manufacturing. |
For quotation comparison, the most useful approach is to normalize each supplier's result to the same potency basis and analytical standard. A reported IU/mg value should not be compared directly with a percentage assay without confirming what each number measures and whether moisture correction has been applied.
Common bulk packaging includes aluminum foil inner bags placed inside fiber drums, with commercial pack sizes such as 1 kg, 5 kg, and 25 kg. Packaging can be customized according to order quantity, transportation conditions, storage requirements, and downstream manufacturing processes.
Colistin sulfate is a regulated veterinary pharmaceutical API rather than a conventional nutraceutical ingredient. Where permitted by the target market, related manufacturing services may include formulation development, finished-product manufacturing, packaging, labeling, and private-label production.
For regulated veterinary products, any customized formulation or finished product should be aligned with the applicable registration, approved specification, dosage form, labeling requirements, antimicrobial-use restrictions, and quality agreement.
Quality control for colistin sulfate should reflect its nature as a mixture of related polymyxin peptide substances. Typical batch-release and incoming-inspection controls include:
Colistin sulfate is commonly identified by CAS 1264-72-8. It represents a sulfate salt of colistin-related peptide substances rather than a conventional single-component small molecule, which is why commercial specifications commonly emphasize potency and composition.
Potency may be expressed in IU/mg or as an equivalent mass of colistin per milligram, depending on the applicable pharmacopoeial or validated method. USP specifies a potency equivalent to not less than 500 micrograms of colistin per milligram, while other standards may use different unit conventions.
Colistin sulfate is a sulfate salt of a mixture of related peptide components, principally colistin A and colistin B. These components have different molecular formulas and molecular weights, so the commercial material is better characterized through composition, potency, and applicable pharmacopoeial testing.
Procurement review should normally cover identity, potency, chromatographic composition or related substances, moisture, sulfate content, appearance, and applicable microbiological quality. Buyers should also confirm the exact analytical standard and potency basis so that different supplier specifications can be compared consistently.
Colistin sulfate should be protected from excessive heat, moisture, contamination, and unsuitable handling. Storage conditions depend on the specific material and packaging configuration, so the applicable product specification and technical documentation should be followed for commercial storage.
Colistin sulfate is a potency-standardized polymyxin E API used primarily in regulated veterinary pharmaceutical applications. For bulk procurement, the critical sourcing variables are potency basis, pharmacopoeial standard, peptide composition, moisture, sulfate content, related substances, packaging, and the regulatory requirements of the destination market.
Contact us today to request samples, a COA, technical documents, and a wholesale quotation for colistin sulfate.
Packaging & Delivery
| Selling Units: | Kilogram |
|---|
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