Contact Now
Send Message
Privacy statement: Your privacy is very important to Us. Our company promises not to disclose your personal information to any external company with out your explicit permission.
Shaanxi Kaishi Biotechnology Co., Ltd
Product Description
Hyaluronic Acid is a naturally occurring glycosaminoglycan widely used as a moisture-binding, rheology-modifying, and functional ingredient in cosmetic, nutritional, and specialty formulations. Commercial HA is commonly produced by microbial fermentation and supplied in different molecular-weight ranges, allowing buyers to select grades for topical hydration, oral beauty products, powders, capsules, and formulation systems.
Hyaluronic Acid is not a small single-molecule ingredient with one fixed molecular weight. It is a linear polysaccharide composed of repeating D-glucuronic acid and N-acetyl-D-glucosamine units, and its functional behavior depends strongly on polymer chain length. For B2B sourcing, molecular-weight range, chemical form, purity, fermentation source, and intended application are therefore more meaningful than the product name alone. :contentReference[oaicite:0]{index=0}
| Item | Specification |
|---|---|
| Product Name | Hyaluronic Acid |
| Product Category | Nutritional Ingredient / Cosmetic Functional Ingredient |
| Synonyms | Hyaluronan, HA |
| CAS Number | 9004-61-9 |
| Molecular Formula | (C14H21NO11)n |
| Molecular Weight | Variable polymer molecular weight; commercial grades are supplied across different molecular-weight ranges rather than one fixed value |
| Structural Unit | Repeating D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units |
| Appearance | White to off-white hygroscopic powder |
| Production Method | Commonly produced by microbial fermentation followed by purification and molecular-weight control |
| Common Commercial Form | Hyaluronic acid or sodium hyaluronate, depending on application and specification |
| Sodium Hyaluronate CAS Number | 9067-32-7 |
| Sodium Hyaluronate Formula | (C14H20NNaO11)n |
| Assay / Purity | High-purity grades are commonly specified by hyaluronic acid or sodium hyaluronate content according to the applicable analytical standard |
| Molecular-Weight Grades | High, medium, low, and very-low molecular-weight grades available according to target application |
| Test Methods | Validated assay methods with molecular-weight determination commonly performed by size-exclusion or gel-permeation chromatography; identity and purity testing selected according to specification |
| Solubility | Forms hydrated or viscous aqueous systems; dissolution behavior depends on molecular weight, concentration, chemical form, and processing conditions |
| Particle Size | Fine powder; customized processing characteristics available according to formulation requirements |
| Quality Testing | Identity, assay, molecular-weight distribution, heavy metals, microbiological parameters, moisture, residual solvents where relevant, and other application-specific quality parameters |
| Shelf Life | Commonly 24 months when stored in suitable sealed packaging under recommended conditions |
| Storage | Store tightly sealed in a cool, dry place away from direct sunlight, heat, and moisture |
| Packaging | 1 kg and 5 kg aluminum foil bags, 25 kg fiber drums, and customized bulk packaging |
| MOQ | Flexible commercial quantities depending on molecular-weight grade, purity, application, and customization requirements |
| Applications | Cosmetic serums, creams, masks, personal care, beauty-from-within supplements, capsules, tablets, powders, functional foods, and specialty formulation systems |
The defining procurement variable for Hyaluronic Acid is molecular weight. HA performance changes substantially as polymer chain length changes, so two ingredients sold under the same name may behave very differently in viscosity, film formation, skin feel, hydration profile, dissolution, and formulation processing. Commercial buyers should therefore specify an acceptable molecular-weight range rather than purchasing HA by purity alone. :contentReference[oaicite:1]{index=1}
| Molecular-Weight Direction | Typical Formulation Behavior | Buyer Consideration |
|---|---|---|
| High Molecular Weight HA | Creates greater solution viscosity and forms a moisture-retaining film on the formulation or skin surface | Useful when surface hydration, rheology, and film-forming characteristics are priorities |
| Medium Molecular Weight HA | Provides an intermediate balance between viscosity, hydration, and formulation handling | Suitable for general-purpose cosmetic and nutritional formulations requiring balanced processing behavior |
| Low Molecular Weight HA | Produces lower viscosity at equivalent concentration and different formulation behavior from high-molecular-weight material | Useful where easier incorporation, lower viscosity, or a differentiated molecular-weight profile is desired |
| Very-Low Molecular Weight or Oligomeric HA | Uses shorter HA chains with distinctly different physicochemical characteristics | Should be purchased against a clearly defined molecular-weight range and application specification rather than generic “low molecular weight” wording |
Terms such as high, low, micro, or oligomeric Hyaluronic Acid are not sufficiently precise for technical purchasing unless the supplier also defines the molecular-weight range and test method. Different commercial products can use different cutoffs, so procurement teams should compare numerical ranges, distribution data, and analytical methods rather than relying only on descriptive grade names.
Molecular-weight control has become a major focus in modern HA production because application behavior is closely related to chain length. Industrial production now commonly uses microbial fermentation, with molecular weight managed through fermentation conditions, strain selection, enzymatic processing, or downstream control. :contentReference[oaicite:2]{index=2}
Hyaluronic Acid and Sodium Hyaluronate are closely related but should not be treated as identical specification names. Sodium hyaluronate is the sodium salt of hyaluronic acid and is widely used in commercial formulations because of its handling and formulation characteristics. USP references describe fermentation-derived sodium hyaluronate as a white or almost white hygroscopic material with variable polymer molecular weight. :contentReference[oaicite:3]{index=3}
| Ingredient | Key Specification | Procurement Relevance |
|---|---|---|
| Hyaluronic Acid | CAS 9004-61-9; polymeric acidic glycosaminoglycan | Confirm molecular-weight range, purity, intended application, and analytical basis |
| Sodium Hyaluronate | CAS 9067-32-7; sodium salt of hyaluronic acid | Widely used in cosmetic, nutritional, and technical formulations and should be specified separately from free-acid HA |
| Hydrolyzed Hyaluronic Acid | Lower-chain-length material produced through hydrolysis | Useful when a deliberately lower molecular-weight profile is required |
| Multi-Molecular-Weight HA System | Combines two or more defined HA molecular-weight grades | Useful for differentiated cosmetic formulations where multiple viscosity and hydration characteristics are desired |
Hyaluronic Acid and Sodium Hyaluronate are widely used in cosmetic formulations because of their strong water-binding properties and useful rheological behavior. Sodium hyaluronate is particularly common in topical products, while commercial cosmetic systems may also use hydrolyzed HA or other molecular-weight variants to create differentiated sensory and hydration profiles. :contentReference[oaicite:4]{index=4}
Hyaluronic Acid is also used in functional food and oral beauty formulations. For these products, buyers should define food- or supplement-appropriate material, molecular-weight specification, purity, serving target, and compatibility with the finished dosage form. Oral formulations may be developed as capsules, tablets, powders, beverages, or gummies according to the target market.
| Application | Recommended Specification Focus | Formulation Logic |
|---|---|---|
| Viscous Cosmetic Serum | High or medium molecular-weight sodium hyaluronate | Prioritizes hydration, viscosity contribution, and surface film formation |
| Lightweight Cosmetic Essence | Lower-viscosity or lower molecular-weight grade | Helps control tack, flow, and finished-product sensory profile |
| Multi-Level Hydration Formula | Blend of defined high and lower molecular-weight grades | Provides formulation differentiation through multiple chain-length fractions rather than one generic HA grade |
| Capsule or Tablet | Food- or supplement-appropriate grade with defined purity and molecular weight | Focuses on dose accuracy, documentation, flow, and finished-product compatibility |
| Gummy or Powder Supplement | Grade selected for processing stability, solubility, dose, and sensory impact | Balances active loading with manufacturability and consumer experience |
Commercial Hyaluronic Acid production has largely shifted from traditional animal-tissue extraction toward microbial fermentation. Fermentation allows scalable manufacturing and provides greater control over purity and molecular-weight development, while avoiding dependence on animal-derived tissues. Modern HA production may use selected microbial or recombinant production systems followed by purification and molecular-weight adjustment. :contentReference[oaicite:5]{index=5}
For procurement, “fermentation-derived” should still be accompanied by a complete technical specification. Buyers should review organism or production-system information where relevant, molecular-weight range, purification standard, microbial limits, endotoxin requirements if applicable to the intended use, and the regulatory status required for the destination market.
Reliable Hyaluronic Acid sourcing requires more than confirming assay. Molecular-weight distribution, identity, purity, moisture, microbial quality, and application-specific contaminants should be controlled because these factors affect both formulation performance and product consistency. Production under GMP-standard conditions can be supported by in-house R&D and analytical testing.
A technically useful Hyaluronic Acid specification should define more than purity. Molecular-weight range determines important aspects of viscosity, processing, hydration behavior, and end-use performance, while the chemical form determines how the material should be handled and labeled. Specifying both parameters makes supplier comparison more meaningful and helps improve batch-to-batch formulation consistency.
Standard bulk packaging includes 1 kg and 5 kg aluminum foil bags and 25 kg fiber drums, with customized formats available for different purchasing programs. Because Hyaluronic Acid and Sodium Hyaluronate are hygroscopic, packaging should remain tightly sealed and protected from moisture, excessive heat, and direct sunlight throughout storage and transportation.
Hyaluronic Acid can be incorporated into customized beauty supplements, capsules, tablets, powders, gummies, and suitable cosmetic products. OEM and private-label programs can include grade selection, molecular-weight strategy, formula development, complementary ingredient selection, finished-product manufacturing, labeling, and retail packaging according to the intended dosage form and market positioning.
Molecular-weight range is one of the most important parameters because it directly affects viscosity, hydration behavior, processing characteristics, and end-use performance. Buyers should also confirm whether the material is Hyaluronic Acid or Sodium Hyaluronate, together with purity, fermentation source, analytical method, microbiological limits, and intended application grade.
Sodium Hyaluronate is the sodium salt of Hyaluronic Acid. The two are chemically related but should be identified separately in technical specifications and product documentation. Sodium Hyaluronate is widely used in commercial cosmetic and nutritional formulations, so buyers should verify the exact chemical form rather than relying on the general abbreviation “HA.”
Do not compare only descriptive terms such as high, low, or micro molecular weight. Request the numerical molecular-weight range, distribution information where relevant, and analytical method. Different suppliers may define these grade names differently, so a clearly quantified specification provides a more reliable basis for formulation development and incoming quality control.
Yes. Microbial fermentation is a major industrial production route for Hyaluronic Acid and Sodium Hyaluronate. For commercial sourcing, buyers should still verify molecular weight, purity, production specification, microbial quality, and application-specific requirements. The appropriate grade should be selected according to whether the final product is cosmetic, nutritional, or another specialty formulation. :contentReference[oaicite:6]{index=6}
Commercial buyers commonly review the COA, TDS, SDS, identity results, assay, molecular-weight specification, test method, microbial limits, heavy metals data, moisture specification, storage information, and application-specific documentation. For formulation projects, the exact chemical form and molecular-weight range should be aligned before samples and commercial batches are compared.
Hyaluronic Acid is a versatile polymeric ingredient used across cosmetics, personal care, functional nutrition, and beauty-from-within products. For professional procurement, selecting the correct molecular-weight range and chemical form is more important than purchasing by HA percentage alone, because these parameters strongly influence processing behavior, viscosity, hydration characteristics, and finished-product performance.
Contact us today to request samples, a COA, technical documents, and a wholesale quotation for Hyaluronic Acid.
Packaging & Delivery
The file is encrypted. Please fill in the following information to continue accessing it
Privacy statement: Your privacy is very important to Us. Our company promises not to disclose your personal information to any external company with out your explicit permission.
Fill in more information so that we can get in touch with you faster
Privacy statement: Your privacy is very important to Us. Our company promises not to disclose your personal information to any external company with out your explicit permission.